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Milk Thistle Extract Silymarin 80%
English Name:Silymarin
CAS No.:65666-07-1
Molecular weight 482.436
Density 1.5±0.1 g/cm3
Boiling point 793.0±60.0 °C at 760 mmHg
Molecular formula C25H22O10
Melting point N/A
Flash point 274.5±26.4 °C
Analysis Method: HPLC
Place of Origin:China
Packaging:1KG/Bag. 25kg/drums
The private label service:1kg/cans 500g/1kg/ Aluminum foil bag
the Capsules OEM service; 0# Capsules 500mg/pcs. 2000pcs/kg in Vacuum bag
CAS No.:65666-07-1
Molecular weight 482.436
Density 1.5±0.1 g/cm3
Boiling point 793.0±60.0 °C at 760 mmHg
Molecular formula C25H22O10
Melting point N/A
Flash point 274.5±26.4 °C
Analysis Method: HPLC
Place of Origin:China
Packaging:1KG/Bag. 25kg/drums
The private label service:1kg/cans 500g/1kg/ Aluminum foil bag
the Capsules OEM service; 0# Capsules 500mg/pcs. 2000pcs/kg in Vacuum bag
Milk Thistle Extract Silymarin 80%
Silymarin is an antioxidant derived from a plant called Milk Thistle. Silymarin can stabilize liver cell membrane,
maintain the integrity of liver cells, so that toxins can not penetrate and destroy the liver, and accelerate the synthesis of liver cell DNA (deoxyribonucleic acid),
can prevent cirrhosis, fatty liver, cholangitis, psoriasis and other diseases, and has liver cancer, prostate cancer,
breast cancer and cervical cancer cell growth and differentiation inhibition.
It is the most effective flavonoid for liver disease found in the world.
Medical navigation: digestive system anatomy (digestive tract, accessory digestive glands, abdominal cavity)/ physiological/developmental/enzyme diseases/congenital/tumors, symptoms/personal surgery, drugs.
English Name:Silymarin
CAS No.:65666-07-1
Molecular weight 482.436
Density 1.5±0.1 g/cm3
Boiling point 793.0±60.0 °C at 760 mmHg
Molecular formula C25H22O10
Melting point N/A
Flash point 274.5±26.4 °C
Analysis Method: HPLC
Place of Origin:China
Packaging:1KG/Bag. 25kg/drums
The private label service:1kg/cans 500g/1kg/ Aluminum foil bag
the Capsules OEM service; 0# Capsules 500mg/pcs. 2000pcs/kg in Vacuum bag
Function;
Scavenging active oxygen species
Eliminate reactive oxygen species directly, resist lipid peroxidation, and maintain the fluidity of cell membrane;
Hepatoprotective effect
Silymarin protects against liver damage caused by carbon tetrachloride, galactosamine, alcohols and other hepatotoxins.
Antitumor effect
Various active oxygen species can oxidize guanine to form 8 - antelope guanine, causing DNA damage, and then causing tumors. The application of antioxidants, especially free radical scavenger can prevent this process.
Anti-cardiovascular effects
ksoottva et al. studied the oxidation effect of milk thistle extract on high cholesterol and low density lipoprotein in mice.
Mice fed with polyunsaturated fatty acid and a small amount of saturated fatty acid containing milk thistle extract showed a significant decrease in serum cholesterol content in the former compared with mice fed with polyunsaturated fatty acid and a small amount of saturated fatty acid.
VLDL hair decreased and HDL-C increased, indicating that silymarin improved the anti-LDL ability.
Protective effect of cerebral ischemic injury
Feng Quan et al. investigated the mechanism of the protective effect of silymarin on ischemic brain injury by creating a rat model of global cerebral ischemia with four-vessel blockade method. By observing the expression levels of nitric oxide and nitric oxide synthase in brain homogenate,
it was shown that silymarin significantly reduced the content of NO and NOS in the cerebral tissue of ischemic rats and significantly reduced the infarct size. Therefore, it is concluded that silymarin can improve the antioxidant capacity of the body and has a significant protective effect on cerebral ischemia injury.
Specification Recommned
Silymarin is an antioxidant derived from a plant called Milk Thistle. Silymarin can stabilize liver cell membrane,
maintain the integrity of liver cells, so that toxins can not penetrate and destroy the liver, and accelerate the synthesis of liver cell DNA (deoxyribonucleic acid),
can prevent cirrhosis, fatty liver, cholangitis, psoriasis and other diseases, and has liver cancer, prostate cancer,
breast cancer and cervical cancer cell growth and differentiation inhibition.
It is the most effective flavonoid for liver disease found in the world.
Medical navigation: digestive system anatomy (digestive tract, accessory digestive glands, abdominal cavity)/ physiological/developmental/enzyme diseases/congenital/tumors, symptoms/personal surgery, drugs.
English Name:Silymarin
CAS No.:65666-07-1
Molecular weight 482.436
Density 1.5±0.1 g/cm3
Boiling point 793.0±60.0 °C at 760 mmHg
Molecular formula C25H22O10
Melting point N/A
Flash point 274.5±26.4 °C
Analysis Method: HPLC
Place of Origin:China
Packaging:1KG/Bag. 25kg/drums
The private label service:1kg/cans 500g/1kg/ Aluminum foil bag
the Capsules OEM service; 0# Capsules 500mg/pcs. 2000pcs/kg in Vacuum bag
| No. | Test items | Specification and Standards | Results |
| 1. | Appearance | Amorphous Powder | Conforms |
| 2. | Colour | Yellow to Yellowish-Brown | Conforms |
| 3. | Odour | Slight, Specific | Conforms |
| 4. | Solubility | ||
| - in Water | Practically Insoluble | Conforms | |
| - in Methanol and Acetone | Soluble | Conforms | |
| 5. | SulphatedAsh | NMT 0.5% | Conforms |
| 6. | Heavy metals | NMT 10 PPM | Conforms |
| 7. | Loss On Drying | NMT 5.0% | 2.9% |
| 8. | Powder size | ||
| Mesh 80 | NLT 90% | Conforms | |
| 9. | Assay of Silymarin ( UV) | NLT 80% | 88.9% |
| Assay of Silymarin (HPLC) | NLT 50% | 52. 1% | |
| -Silybin A.B. | 33.5% | ||
| -Isosilybin A.B. | 5.7% | ||
| -Silydianin&Silychristin | 12.9% | ||
| 10. | Residual Solvents | ||
| - N-hexane | NMT 0.029% | Conforms | |
| - Methanol | NMT 0.3% | Conforms | |
| -Acetone | NMT 0.5% | Conforms | |
| - Ethyl Acetate | NMT 0.5% | Conforms | |
| - Ethanol | NMT 0.5% | Conforms | |
| 11. | Microbiological Quality (Total viable aerobic count) | ||
| - Total bacterial count | NMT 1,000.0 CFU/g | Conforms | |
| - Moulds & Yeasts | NMT 100.0 CFU/g | Conforms | |
| - Escherichia coli | Not detected | Conforms | |
| - Salmonellaspecies | Not detected | Conforms | |
Function;
Scavenging active oxygen species
Eliminate reactive oxygen species directly, resist lipid peroxidation, and maintain the fluidity of cell membrane;
Hepatoprotective effect
Silymarin protects against liver damage caused by carbon tetrachloride, galactosamine, alcohols and other hepatotoxins.
Antitumor effect
Various active oxygen species can oxidize guanine to form 8 - antelope guanine, causing DNA damage, and then causing tumors. The application of antioxidants, especially free radical scavenger can prevent this process.
Anti-cardiovascular effects
ksoottva et al. studied the oxidation effect of milk thistle extract on high cholesterol and low density lipoprotein in mice.
Mice fed with polyunsaturated fatty acid and a small amount of saturated fatty acid containing milk thistle extract showed a significant decrease in serum cholesterol content in the former compared with mice fed with polyunsaturated fatty acid and a small amount of saturated fatty acid.
VLDL hair decreased and HDL-C increased, indicating that silymarin improved the anti-LDL ability.
Protective effect of cerebral ischemic injury
Feng Quan et al. investigated the mechanism of the protective effect of silymarin on ischemic brain injury by creating a rat model of global cerebral ischemia with four-vessel blockade method. By observing the expression levels of nitric oxide and nitric oxide synthase in brain homogenate,
it was shown that silymarin significantly reduced the content of NO and NOS in the cerebral tissue of ischemic rats and significantly reduced the infarct size. Therefore, it is concluded that silymarin can improve the antioxidant capacity of the body and has a significant protective effect on cerebral ischemia injury.
Specification Recommned
| Extract | Specification |
| ACETONE | Silybin +Isosilybin 30 HPLC |
| Silybin30%HPLC | |
| Silymarin 40% HPLC | |
| Silymarin 50% HPLC | |
| Silymarin 55% HPLC | |
| Silymarin 60% HPLC | |
| Silymarin 80% UV | |
| Ethanol | Silybin +Isosilybin 30 HPLC |
| Silybin30%HPLC | |
| Silymarin 40% HPLC | |
| Silymarin 50% HPLC | |
| Silymarin 60% HPLC | |
| Ethyl Acetate | Silymarin 50% HPLC |
| Silymarin 55% HPLC | |
| Silymarin 60% HPLC | |
| water soluble silymarin | Silymarin 20% HPLC |
| Silymarin 35% HPLC | |
| Silymarin 40% UV | |
| Silymarin 45% UV | |
| Silymarin 50% UV |
