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Uses and Synthesis of Cepharanthine
Cepharanthine has potential antitumor effects.
Cepharanthine alone can play an anti-tumor effect by inhibiting tumor cell proliferation and enhancing the body's immunity.
What is more promising is that Cepharanthine combined with chemotherapeutic drugs improves the efficacy of chemotherapy by reducing the drug resistance of cells. The main mechanism may be that Cepharanthine increases the accumulation of anticancer drugs in cells by interfering with the function of the plasma membrane. In addition, Cepharanthine also increases the sensitivity of tumor cells to radiotherapy.
Direct anti-tumor effect of Cepharanthine: Cepharanthine can enhance the body's anti-tumor ability by enhancing the body's immune response.
Macrophages can specifically recognize and kill tumor cells and play a crucial role in anti-tumor immunity. However, in individuals with tumorigenesis, macrophages are often inhibited.
Chrysanthin can activate macrophages, which may be related to its effect on tumor therapy. In addition, the activation of chitosan by T cells or direct action on macrophages is an important mechanism of tumor inhibition.
Cepharanthine exerts its anti-tumor effect by enhancing the body's anti-tumor immunity by acting on macrophages, T cells, NK cells, etc. Cepharanthine may be a multi-target and multi-effect drug, and its anti-tumor pharmacology is complex, and its molecular mechanism remains to be further explored.
Based on the experimental results in a variety of tumor cells, the anti-tumor effect of Cepharanthine is affirmative.
Cepharanthine increases the sensitivity of tumor cells to chemotherapy:
The resistance of tumor cells to various chemotherapeutic drugs is a major obstacle in various cancer chemotherapy. The phenomenon that tumor cells are resistant to a variety of cytotoxic drugs with different structures and properties is called multidrug resistance. Cepharanthine has the effect of eliminating MDR.
A possible mechanism by which cepharanthine increases the accumulation of chemotherapeutic drugs in tumor cells is that it interacts directly with P-gp or binds to phosphatidylserine in the plasma membrane to eliminate MDR.
By interfering with the function of the plasma membrane, it promotes the accumulation of anticancer drugs in MDR cells, thereby improving the efficacy of anticancer drugs.
Cepharanthine can inhibit the transport function of P-gp, so it has an inhibitory effect on the drug resistance of many MDR cells that highly express P-gp. Intracellular accumulation and reversal of MRP7-mediated MDR
Cepharanthine alone can play an anti-tumor effect by inhibiting tumor cell proliferation and enhancing the body's immunity.
What is more promising is that Cepharanthine combined with chemotherapeutic drugs improves the efficacy of chemotherapy by reducing the drug resistance of cells. The main mechanism may be that Cepharanthine increases the accumulation of anticancer drugs in cells by interfering with the function of the plasma membrane. In addition, Cepharanthine also increases the sensitivity of tumor cells to radiotherapy.
Direct anti-tumor effect of Cepharanthine: Cepharanthine can enhance the body's anti-tumor ability by enhancing the body's immune response.
Macrophages can specifically recognize and kill tumor cells and play a crucial role in anti-tumor immunity. However, in individuals with tumorigenesis, macrophages are often inhibited.
Chrysanthin can activate macrophages, which may be related to its effect on tumor therapy. In addition, the activation of chitosan by T cells or direct action on macrophages is an important mechanism of tumor inhibition.
Cepharanthine exerts its anti-tumor effect by enhancing the body's anti-tumor immunity by acting on macrophages, T cells, NK cells, etc. Cepharanthine may be a multi-target and multi-effect drug, and its anti-tumor pharmacology is complex, and its molecular mechanism remains to be further explored.
Based on the experimental results in a variety of tumor cells, the anti-tumor effect of Cepharanthine is affirmative.
Cepharanthine increases the sensitivity of tumor cells to chemotherapy:
The resistance of tumor cells to various chemotherapeutic drugs is a major obstacle in various cancer chemotherapy. The phenomenon that tumor cells are resistant to a variety of cytotoxic drugs with different structures and properties is called multidrug resistance. Cepharanthine has the effect of eliminating MDR.
A possible mechanism by which cepharanthine increases the accumulation of chemotherapeutic drugs in tumor cells is that it interacts directly with P-gp or binds to phosphatidylserine in the plasma membrane to eliminate MDR.
By interfering with the function of the plasma membrane, it promotes the accumulation of anticancer drugs in MDR cells, thereby improving the efficacy of anticancer drugs.
Cepharanthine can inhibit the transport function of P-gp, so it has an inhibitory effect on the drug resistance of many MDR cells that highly express P-gp. Intracellular accumulation and reversal of MRP7-mediated MDR
